DeFi development requires a strong focus on security, as smart contract vulnerabilities can lead to financial loss. Choosing the right blockchain is crucial for Flexibility, speed, and cost efficiency. Well-planned liquidity and tokenomics ensure sustainability, while regulatory compliance helps avoid legal issues. Cross-chain compatibility enhances accessibility, and a user-friendly experience encourages adoption. Decentralized governance (DAOs) improves transparency, and strict testing & audits help prevent risks.